Isosteric Phosphonate Pyrrolidine-Based Dinucleoside Monophosphate Analogues.

Authors :: Vaněk, Václav
Buděšínský, Miloš
Kavenová, Ivana
Rinnová, Markéta
Rosenberg, Ivan
Source :: Nucleosides, Nucleotides & Nucleic Acids; May2003, Vol. 22 Issue 5-8, p1065-1067, 3p
Publication Year :: 2003
Abstract: A novel α- and β-configured pyrrolidine nucleoside phosphonates in adenine series were synthesized from trans-4-hydroxy-L-proline as starting material. d(ApA) analogues were also prepared and studied with respect to their hybridization properties with polyU. [ABSTRACT FROM AUTHOR]