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Validation of the revised international prognostic scoring system ( IPSS-R) in patients with lower-risk myelodysplastic syndromes: a report from the prospective European LeukaemiaNet MDS ( EUMDS) registry.
- Source :
- British Journal of Haematology; Aug2015, Vol. 170 Issue 3, p372-383, 12p, 1 Diagram, 3 Charts, 2 Graphs
- Publication Year :
- 2015
-
Abstract
- Baseline characteristics, disease-management and outcome of 1000 lower-risk myelodysplastic syndrome ( MDS) patients within the European LeukaemiaNet MDS ( EUMDS) Registry are described in conjunction with the validation of the revised International Prognostic Scoring System ( IPSS-R). The EUMDS registry confirmed established prognostic factors, such as age, gender and World Health Organization 2001 classification. Low quality of life ( EQ-5D visual analogue scale score) was significantly associated with reduced survival. A high co-morbidity index predicted poor outcome in univariate analyses. The IPSS-R identified a large group of 247 patients with Low (43%) and Very low (23%) risk score within the IPSS intermediate-1 patients. The IPSS-R also identified 32 High or Very high risk patients within the IPSS intermediate-1 patients. IPSS-R was superior to the IPSS for predicting both disease progression and survival. Seventy percent of patients received MDS-specific treatment or supportive care, including red blood cell transfusions (51%), haematopoietic growth factors (58%) and iron chelation therapy (8%), within 2 years of diagnosis; while 30% of the patients only required active monitoring. The IPSS-R proved its utility as a more refined risk stratification tool for the identification of patients with a very good or poor prognosis and in this lower-risk MDS population. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00071048
- Volume :
- 170
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- British Journal of Haematology
- Publication Type :
- Academic Journal
- Accession number :
- 108350582
- Full Text :
- https://doi.org/10.1111/bjh.13450