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Homogeneous synthesis of amino-reserved chitosan-graft-polycaprolactone in an ionic liquid and the application in cell cultivation.
- Source :
- Polymer International; Aug2015, Vol. 64 Issue 8, p1045-1052, 8p
- Publication Year :
- 2015
-
Abstract
- The homogeneous preparation of amino-reserved chitosan-graft-polycaprolactone copolymer (ACS-g-PCL) was achieved in 1-butyl-3-methylimidazolium acetate via a protection-ring-opening graft polymerization-deprotection procedure. The molar substitution of PCL (MS<subscript>PCL</subscript>) in ACS-g-PCL copolymers was in the range 17.1-45.6 and could be well controlled by altering reaction conditions. The resultant ACS-g-PCL copolymers were soluble in some common organic solvents such as dimethylsulfoxide, ethanol and toluene. As the increment of MS<subscript>PCL</subscript> increased, the hydrophilicity of the ACS-g-PCL copolymers decreased. Eventually, ACS-g-PCL microspheres with a diameter of 100-200 μm were fabricated by an emulsion evaporation method. Among them, the ACS-g-PCL copolymer with an MS<subscript>PCL</subscript> of 26.8 formed into porous microspheres. The fluorescence microscopy and cytotoxicity results suggested that all of the microspheres, especially the ACS-g-PCL microspheres with MS<subscript>PCL</subscript> of 17.1 and 26.8, showed high cell adhesion and cytocompatibility to the human osteosarcoma cell line (MG-63), indicating their great prospects in tissue engineering. [ABSTRACT FROM AUTHOR]
- Subjects :
- CHITOSAN
POLYCAPROLACTONE
AMINO acids
MICROSPHERES
CELL culture
Subjects
Details
- Language :
- English
- ISSN :
- 09598103
- Volume :
- 64
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Polymer International
- Publication Type :
- Academic Journal
- Accession number :
- 108796301
- Full Text :
- https://doi.org/10.1002/pi.4912