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Resistant hypertension: do all definitions describe the same patients?

Authors :
Boswell, L
Pascual, J
Oliveras, A
Source :
Journal of Human Hypertension; Sep2015, Vol. 29 Issue 9, p530-534, 5p, 4 Charts
Publication Year :
2015

Abstract

Resistant hypertension (RH) is defined as blood pressure (BP) that remains ⩾140 and/or 90 mm Hg despite therapy with ⩾3 full-dose antihypertensive drugs (classical definition=CD). A definition proposed subsequently (new definition=ND) includes patients requiring ⩾4 drugs irrespective of BP values. We aimed to evaluate whether both definitions characterize the same kind of patients.One hundred and twenty-four consecutively attended patients with RH were classified into two groups according to their BP control: 66 patients had non-controlled BP (all those who met the CD criteria plus a few patients who met the ND criteria); 58 patients had controlled BP (all with RH according to the ND). Clinical, laboratory and office BP data were recorded. RH patients with non-controlled BP were more frequently diabetic (72% vs 49%), and had higher plasmatic glucose (149 vs 130 mg dl<superscript>−1</superscript>), cholesterol (179 vs 164 mg dl<superscript>−1</superscript>), low-density lipoprotein (LDL)-cholesterol (107 vs 95 mg dl<superscript>−1</superscript>) and triglyceride (169 vs 137 mg dl<superscript>−1</superscript>) levels; P<0.05 for all comparisons. In multivariate logistic regression analysis, the variables that independently associated with non-controlled BP were diabetes (P=0.001) and higher LDL-cholesterol (P=0.007).We conclude that, although both cohorts of patients are phenotypically quite similar, uncontrolled RH patients have higher prevalence of diabetes mellitus and higher LDL-cholesterol levels than controlled RH patients. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09509240
Volume :
29
Issue :
9
Database :
Complementary Index
Journal :
Journal of Human Hypertension
Publication Type :
Academic Journal
Accession number :
108831759
Full Text :
https://doi.org/10.1038/jhh.2014.128