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Use of Contrast-Enhanced Ultrasound to Study Relationship between Serum Uric Acid and Renal Microvascular Perfusion in Diabetic Kidney Disease.
- Source :
- BioMed Research International; 5/26/2015, Vol. 2015, p1-10, 10p
- Publication Year :
- 2015
-
Abstract
- Purpose. To investigate the relationship between uric acid and renal microvascular perfusion in diabetic kidney disease (DKD) using contrast-enhanced ultrasound (CEUS) method. Materials and Methods. 79 DKD patients and 26 healthy volunteers were enrolled. Renal function and urine protein markers were tested. DKD patients were subdivided into two groups including a normal serum uric acid (SUA) group and a high SUA group. Contrast-enhanced ultrasound (CEUS) was performed, and low acoustic power contrast-specific imaging was used for quantitative analysis. Results. Normal controls (NCs) had the highest levels of AUC, AUC1, and AUC2. Compared to the normal SUA DKD group, high SUA DKD patients had significantly higher IMAX, AUC, and AUC1 (P<0.05). DKD patients with low urinary uric acid (UUA) excretion had significantly higher AUC2 compared to DKD patients with normal UUA (P<0.05). Conclusion. Hyperuricemia in DKD patients was associated with a renal ultrasound image suggestive of microvascular hyperperfusion. The CEUS parameter AUC1 holds promise as an indicator for renal microvascular hyperperfusion, while AUC2 might be a useful indicator of declining glomerular filtration rate in DKD patients with decreased excretion of uric acid. [ABSTRACT FROM AUTHOR]
- Subjects :
- KIDNEY physiology
ACADEMIC medical centers
BIOMARKERS
CHI-squared test
DIABETIC nephropathies
MICROCIRCULATION
RESEARCH funding
ULTRASONIC imaging
URIC acid
CONTRAST media
CASE-control method
RECEIVER operating characteristic curves
DATA analysis software
DESCRIPTIVE statistics
MANN Whitney U Test
KRUSKAL-Wallis Test
ONE-way analysis of variance
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Volume :
- 2015
- Database :
- Complementary Index
- Journal :
- BioMed Research International
- Publication Type :
- Academic Journal
- Accession number :
- 109274395
- Full Text :
- https://doi.org/10.1155/2015/732317