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Sub-population analysis of deformability distribution in heterogeneous red blood cell population.
- Source :
- Biomedical Microdevices; Dec2015, Vol. 17 Issue 6, p1-5, 5p
- Publication Year :
- 2015
-
Abstract
- We present a method for sub-population analysis of deformability distribution using single-cell microchamber array (SiCMA) technology. It is a unique method allowing the correlation of overall cellular characteristics with surface and cytosolic characteristics to define the distribution of individual cellular characteristics in heterogeneous cell populations. As a proof of principle, reticulocytes, the immature sub-population of red blood cells (RBC), were recognized from RBC population by a surface marker and different characteristics on deformability between these populations were characterized. The proposed technology can be used in a variety of applications that would benefit from the ability to measure the distribution of cellular characteristics in complex populations, especially important to define hematologic disorders. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13872176
- Volume :
- 17
- Issue :
- 6
- Database :
- Complementary Index
- Journal :
- Biomedical Microdevices
- Publication Type :
- Academic Journal
- Accession number :
- 109504103
- Full Text :
- https://doi.org/10.1007/s10544-015-0007-1