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Maintenance of improvement in spinal mobility, physical function and quality of life in patients with ankylosing spondylitis after 5 years in a clinical trial of adalimumab.
- Source :
- Rheumatology; Jul2015, Vol. 54 Issue 7, p1210-1219, 10p, 4 Charts, 2 Graphs
- Publication Year :
- 2015
-
Abstract
- Objective. Chronic pain and progressive loss of physical function with AS may adversely affect health-related quality of life (HRQoL). The objective of this study was to assess the 5-year data regarding spinal mobility, physical function and HRQoL in patients with AS who participated in the Adalimumab Trial Evaluating Long-term Efficacy and Safety for AS (ATLAS) study. Methods. Patients received blinded adalimumab 40mg or placebo every other week for 24 weeks, then open-label adalimumab for up to 5 years. Spinal mobility was evaluated using linear BASMI (BASMI<subscript>lin</subscript>). BASDAI, total back pain, CRP, BASFI, Short Form-36 and AS quality of life (ASQoL) were also assessed. Correlations between BASMI<subscript>lin</subscript> and clinical, functional and ASQoL outcomes after 12 weeks and after 5 years of adalimumab exposure were evaluated using Spearman's rank correlation. Associations were further analysed using multivariate regression. Results. Three hundred and eleven patients received 51 dose of adalimumab; 125 of the 208 patients originally randomized to adalimumab received treatment for 5 years. Improvements in BASMI<subscript>lin</subscript> were sustained through 5 years, with a mean change of -0.6 from baseline in the population who completed 5 years of treatment with adalimumab. Improvements in disease activity, physical function and ASQoL were also sustained through 5 years. BASMI<subscript>lin</subscript> was significantly correlated with all evaluated clinical outcomes (P<0.001). The highest correlation was with BASFI at 12 weeks (r = 0.52) and at 5 years (r = 0.65). Multivariate regression analysis confirmed this association (P<0.001). Conclusion. Treatment with adalimumab for up to 5 years demonstrated sustained benefits in spinal mobility, disease activity, physical function and HRQoL in patients with active AS. Spinal mobility was significantly associated with short- and long-term physical function in these patients. [ABSTRACT FROM AUTHOR]
- Subjects :
- SPINE physiology
ADALIMUMAB
ACADEMIC medical centers
ANKYLOSING spondylitis
LONGITUDINAL method
MULTIVARIATE analysis
PLACEBOS
QUALITY of life
QUESTIONNAIRES
REGRESSION analysis
RESEARCH funding
STATISTICS
WORLD health
DATA analysis
RANDOMIZED controlled trials
TREATMENT effectiveness
BLIND experiment
PHYSICAL activity
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 14620324
- Volume :
- 54
- Issue :
- 7
- Database :
- Complementary Index
- Journal :
- Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 109926173
- Full Text :
- https://doi.org/10.1093/rheumatology/keu438