Back to Search
Start Over
Anti-hyperalgesic activity of crude extract and 7-methyljuglone of Diospyros lotus roots.
- Source :
- Natural Product Research; Dec2015, Vol. 29 Issue 23, p2226-2229, 4p
- Publication Year :
- 2015
-
Abstract
- This study was designed to evaluate the antihyperalgesic effect of crude extract ofDiospyros lotusfollowed by the isolation and characterisation of 7-methyljuglone in acetic acid and formalin tests. The pretreatment of crude extract evoked dose-dependent inhibition of noxious stimulation with maximum effect of 56.78% in acetic acid-induced writhing test, which were 51.89% and 60.69% in first and second phases, respectively, at 100 mg/kg i.p. The structure of 7-methyljuglone was confirmed by spectroscopic analysis. 7-Methyljuglone evoked profound increase in pain threshhold dose dependently; when it was studied in acetic acid-induced writhing test with 63.73% pain attenuation while 51.22% and 65.44% pain amelioration in first and second phases, respectively, at 100 mg/kg i.p. In conclusion, crude extract and 7-methyljuglone ofD. lotusroots possessed both peripheral and central antinociceptive potential and thus could be a useful new therapeutic agent. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 14786419
- Volume :
- 29
- Issue :
- 23
- Database :
- Complementary Index
- Journal :
- Natural Product Research
- Publication Type :
- Academic Journal
- Accession number :
- 109968869
- Full Text :
- https://doi.org/10.1080/14786419.2014.1003297