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A surface-adaptive nanocarrier to prolong circulation time and enhance cellular uptake.

Authors :
Cheng, Tangjian
Ma, Rujiang
Zhang, Yumin
Ding, Yuxun
Liu, Jinjian
Ou, Hanlin
An, Yingli
Liu, Jianfeng
Shi, Linqi
Source :
Chemical Communications; 10/18/2015, Vol. 51 Issue 81, p14985-14988, 4p
Publication Year :
2015

Abstract

Based on the protonation/deprotonation of poly(β-amino ester) (PAE), mixed-shell micelles (MSMs) with adaptive surfaces could rapidly and reversibly change surface properties to prolong circulation time in blood (pH 7.4) and enhance cellular uptake at tumor sites (pH 6.5). [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
13597345
Volume :
51
Issue :
81
Database :
Complementary Index
Journal :
Chemical Communications
Publication Type :
Academic Journal
Accession number :
110097456
Full Text :
https://doi.org/10.1039/c5cc05854f