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Colorimetric and fluorescence detection of G-quadruplex nucleic acids with a coumarin–benzothiazole probe.
- Source :
- Analyst; 11/7/2015, Vol. 140 Issue 21, p7146-7149, 4p
- Publication Year :
- 2015
-
Abstract
- A colorimetric and red-emitting fluorescent dual probe for G-quadruplexes was devised with a conjugated coumarin–benzothiazole scaffold. Its significant and distinct changes in both color and fluorescence enable the label-free and visual detection of G-quadruplex structures. In addition, this probe gives a distinct strong emission response to the nucleoli in fixed cells imaging, which might be attributed to the interaction between the probe and rDNA G-quadruplex based on the chromatin immunoprecipitation assay. All these results suggest its promising application prospects in the G-quadruplex research field. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00032654
- Volume :
- 140
- Issue :
- 21
- Database :
- Complementary Index
- Journal :
- Analyst
- Publication Type :
- Academic Journal
- Accession number :
- 110266387
- Full Text :
- https://doi.org/10.1039/c5an01573a