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Determinants of parathyroid hormone response to vitamin D supplementation: a systematic review and meta-analysis of randomised controlled trials.
- Source :
- British Journal of Nutrition; 11/14/2015, Vol. 114 Issue 9, p1360-1374, 15p
- Publication Year :
- 2015
-
Abstract
- This systematic review aimed to assess the determinants of the parathyroid hormone (PTH) level response to vitamin D supplementation. We searched Medline, Google Scholar and the reference lists of previous reviews. All randomised controlled trials (RCT) on vitamin D supplementation that involved apparently healthy human subjects with a report of PTH were selected. Potential studies were screened independently and in duplicate. Results are summarised as mean differences with 95 % confidence intervals. Quality assessment, subgroup analysis, meta-analysis and meta-regression analysis were carried out. Thirty-three vitamin D supplementation RCT were included. Vitamin D supplementation significantly raised circulating 25-hydroxyvitamin D (25(OH)D) with significant heterogeneity among studies with a pooled mean difference (PMD) of 15.5 ng/ml (test for heterogeneity: P<0·001 and I2=97·3 %). Vitamin D supplementation significantly reduced PTH level with PMD of −8·0 pg/ml, with significant heterogeneity ((test for heterogeneity: P<0·001) and the I2 value was 97·3 %). In the subgroup analyses, the optimum treatment effect for PTH was observed with Ca doses of 600–1200 mg/d (−22·48 pg/ml), after the duration of a >12-month trial (−18·36 pg/ml), with low baseline 25(OH)D concentration of <20 ng/ml (−16·70 pg/ml) and in those who were overweight and obese (−18·11 pg/ml). Despite the present meta-analysis being hindered by some limitations, it provided some interesting evidence, suggesting that suppression of PTH level needs higher vitamin D intake (75 μg/d) than the current recommendations and longer durations (12 months), which should be taken into account for nutritional recommendations. [ABSTRACT FROM AUTHOR]
- Subjects :
- CONFIDENCE intervals
DIETARY supplements
RESEARCH methodology
MEDLINE
META-analysis
PARATHYROID hormone
PROBABILITY theory
REGRESSION analysis
RESEARCH funding
VITAMIN D
SYSTEMATIC reviews
EVIDENCE-based medicine
PROFESSIONAL practice
RANDOMIZED controlled trials
PUBLICATION bias
DATA analysis software
Subjects
Details
- Language :
- English
- ISSN :
- 00071145
- Volume :
- 114
- Issue :
- 9
- Database :
- Complementary Index
- Journal :
- British Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 110334218
- Full Text :
- https://doi.org/10.1017/S0007114515003189