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Impact of a cognitive rehabilitation intervention on neuropsychiatric symptoms in mild to moderate Alzheimer's disease.
- Source :
- Neuropsychological Rehabilitation; Oct2015, Vol. 25 Issue 5, p677-707, 31p
- Publication Year :
- 2015
-
Abstract
- The main goal of this study was to evaluate the impact of a cognitive rehabilitation programme on 12 behavioural and psychological symptoms of dementia (BPSD) in patients with mild to moderate Alzheimer's disease (AD). This six-month single-blind block-randomised cross-over controlled study was conducted with 15 mild to moderate AD participants and their caregivers. All participants received a four-week home-based cognitive rehabilitation programme to learn/re-learn an instrumental activity of daily living. They were assessed up until three months following the end of the intervention. The Neuropsychiatric Inventory (NPI-12) was employed to evaluate patients' BPSD at seven assessment points during the course of the study. A general linear mixed model analysis performed on the NPI data revealed that aberrant motor behaviours (AMB) increased significantly more in the treatment condition than in the control condition. In addition, both groups registered a significant reduction of delusional symptoms during the second half of the study. Employing a multi-symptom approach to assess participants' BPSD, this cross-over randomised controlled study showed that an individualised cognitive rehabilitation intervention was generally well-tolerated by mild to moderate AD patients. Future cognitive rehabilitation studies conducted with this population should pay attention to AMB symptom changes. [ABSTRACT FROM AUTHOR]
- Subjects :
- ALZHEIMER'S disease
COGNITION
COMPARATIVE studies
CROSSOVER trials
NEUROPSYCHOLOGICAL tests
RESEARCH methodology
MEDICAL cooperation
RESEARCH
ACTIVITIES of daily living
EVALUATION research
RANDOMIZED controlled trials
TREATMENT effectiveness
BLIND experiment
REHABILITATION of Alzheimer's patients
PSYCHOLOGY
Subjects
Details
- Language :
- English
- ISSN :
- 09602011
- Volume :
- 25
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Neuropsychological Rehabilitation
- Publication Type :
- Academic Journal
- Accession number :
- 110369806
- Full Text :
- https://doi.org/10.1080/09602011.2014.964731