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The prognostic value of CXC-chemokine receptor 2 (CXCR2) in gastric cancer patients.
- Source :
- BMC Cancer; 10/23/2015, Vol. 15, p1-8, 8p, 1 Color Photograph, 1 Chart, 3 Graphs
- Publication Year :
- 2015
-
Abstract
- <bold>Background: </bold>CXC chemokine receptor 2 (CXCR2) has been reported to play an important role in the proliferation and invasion of gastric cancer cells. The present study aims to investigate the impact of CXCR2 expression on the overall survival (OS) of gastric cancer patients after radical resection.<bold>Methods: </bold>Intratumoral CXCR2 expression was evaluated with immunohistochemistry on tissue microarrays containing tumor samples of 357 gastric cancer patients from a single center. CXCR2 expression levels were correlated to clinicopathological variables and OS.<bold>Results: </bold>CXCR2 expression was mainly located in the cytoplasm of gastric carcinoma cells. High CXCR2 expression was associated with poor tumor differentiation (p = 0.021), increased tumor depth (p < 0.001), lymph node metastasis (p < 0.001), advanced TNM stage (p < 0.001) and short OS (p = 0.001). CXCR2 expression was an independent prognostic factor for OS (p = 0.001) in multivariate analysis, and could be combined with TNM stage to generate a predictive nomogram for clinical outcome in patients with gastric cancer.<bold>Conclusion: </bold>Intratumoral CXCR2 expression is a novel independent predictor for survival in gastric cancer patients. CXCR2 might be a promising therapeutic target of postoperative adjuvant treatment. [ABSTRACT FROM AUTHOR]
- Subjects :
- STOMACH cancer patients
CHEMOKINE receptors
STOMACH cancer
CANCER cell proliferation
IMMUNOHISTOCHEMISTRY
HEALTH outcome assessment
PROGNOSIS
CANCER-related mortality
CANCER
CELL receptors
CYTOPLASM
METASTASIS
MULTIVARIATE analysis
STOMACH tumors
PREDICTIVE tests
RETROSPECTIVE studies
KAPLAN-Meier estimator
Subjects
Details
- Language :
- English
- ISSN :
- 14712407
- Volume :
- 15
- Database :
- Complementary Index
- Journal :
- BMC Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 110585384
- Full Text :
- https://doi.org/10.1186/s12885-015-1793-9