Synthesis and In Vitro Cytotoxic Activity of Novel Triazole-Isoxazole Derivatives.

Authors :: Najafi, Zahra
Mahdavi, Mohammad
Safavi, Maliheh
Saeedi, Mina
Alinezhad, Heshmatollah
Pordeli, Mahboobeh
Kabudanian Ardestani, Sussan
Shafiee, Abbas
Foroumadi, Alireza
Akbarzadeh, Tahmineh
Source :: Journal of Heterocyclic Chemistry; Nov2015, Vol. 52 Issue 6, p1743-1747, 5p
Publication Year :: 2015
Abstract: New derivatives of triazole-isoxazole were synthesized through a four-step reaction starting from various ethyl 4-aryl-2,4-dioxobutanoate derivatives. Finally, all compounds were examined by MTT assays for cytotoxic activity in two human breast cancer cell lines (MCF-7 and T-47D). [ABSTRACT FROM AUTHOR]

Subjects :: CHEMICAL derivatives
CHEMICAL reactions
TRIAZOLES synthesis
ISOXAZOLES
BREAST cancer research
CELL lines

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