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Extensive cerebral microbleeds predict parenchymal haemorrhage and poor outcome after intravenous thrombolysis.
- Source :
- Journal of Neurology, Neurosurgery & Psychiatry; Nov2015, Vol. 86 Issue 11, p1267-1272, 6p, 4 Charts
- Publication Year :
- 2015
-
Abstract
- <bold>Purpose: </bold>Thrombolysis-related haemorrhagic transformation (HT) subtypes may have different prognostic implications. We aimed to analyse the impact of cerebral microbleeds (CMBs) burden on HT subtypes and outcome after intravenous thrombolysis.<bold>Methods: </bold>We retrospectively examined clinical and radiological data from 333 consecutive patients with acute ischaemic stroke who underwent susceptibility-weighted imaging before intravenous thrombolysis. Logistic regression analysis was used to determine the impact of CMBs on HT subtypes and neurological outcome.<bold>Results: </bold>We observed 596 CMBs in 119 (39.7%) patients on initial gradient-recalled echo scans. HT occurred in 88 (29.3%) patients, among which 62 were haemorrhagic infarction and 26 were parenchymal haemorrhage (PH). Logistic regression analysis indicated that the presence of extensive (≥ 3) CMBs was independently associated with PH (OR 6.704; 95% CI 2.054 to 21.883; p = 0.002) and poor clinical outcome (OR 2.281; 95% CI 1.022 to 5.093; p = 0.044).<bold>Conclusions: </bold>The presence of extensive (≥ 3) CMBs increased the risk of PH 24 h after intravenous thrombolysis, and predicted poor clinical outcome independently. [ABSTRACT FROM AUTHOR]
- Subjects :
- CEREBRAL hemorrhage
THROMBOLYTIC therapy
PROGNOSIS
STROKE
RETROSPECTIVE studies
LOGISTIC regression analysis
MAGNETIC resonance imaging
MANN Whitney U Test
CEREBRAL hemorrhage treatment
STROKE treatment
INFARCTION
LONGITUDINAL method
REGRESSION analysis
RESEARCH evaluation
TREATMENT effectiveness
PREDICTIVE tests
DISEASE progression
DIAGNOSIS
Subjects
Details
- Language :
- English
- ISSN :
- 00223050
- Volume :
- 86
- Issue :
- 11
- Database :
- Complementary Index
- Journal :
- Journal of Neurology, Neurosurgery & Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 110638986
- Full Text :
- https://doi.org/10.1136/jnnp-2014-309857