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Increased circulating follicular helper T cells with decreased programmed death-1 in chronic renal allograft rejection.
- Source :
- BMC Nephrology; 11/3/2015, Vol. 15, p1-6, 6p
- Publication Year :
- 2015
-
Abstract
- <bold>Background: </bold>Chronic antibody-mediated rejection is a major issue that affects long-term renal allograft survival. Since follicular helper T (Tfh) cells promote the development of antigen-specific B cells in alloimmune responses, we investigated the potential roles of Tfh cells, B cells and their alloimmune-regulating molecules in the pathogenesis of chronic renal allograft rejection in this study.<bold>Methods: </bold>The frequency of Tfh, B cells and the levels of their alloimmune-regulating molecules including chemokine receptor type 5 (CXCR5), inducible T cell co-stimulator (ICOS), programmed death-1 (PD-1), ICOSL, PDL-1 and interleukin-21 (IL-21), of peripheral blood were comparatively measured in 42 primary renal allograft recipients within 1-3 years after transplantation. Among them, 24 patients had definite chronic rejection, while other 18 patients had normal renal function.<bold>Results: </bold>Tfh-cell ratio was significantly increased with PD-1 down-regulation in the patients with chronic renal allograft rejection, while B cells and the alloimmune-regulating molecules studied did not show any appreciable change in parallel.<bold>Conclusions: </bold>The patients with chronic renal allograft rejection have a characteristic increase in circulating Tfh cells with a decrease in PD-1 expression. These pathological changes may be a therapeutic target for the treatment of chronic renal allograft rejection and can be useful as a clinical index for monitoring conditions of renal transplant. [ABSTRACT FROM AUTHOR]
- Subjects :
- T helper cells
PROGRAMMED cell death 1 receptors
TREATMENT of chronic kidney failure
KIDNEY transplantation
GRAFT rejection
INTERLEUKIN-21
ANTIGENS
B cells
CHRONIC diseases
COMPARATIVE studies
HOMOGRAFTS
RESEARCH methodology
MEDICAL cooperation
RESEARCH
RESEARCH funding
T cells
EVALUATION research
TREATMENT effectiveness
Subjects
Details
- Language :
- English
- ISSN :
- 14712369
- Volume :
- 15
- Database :
- Complementary Index
- Journal :
- BMC Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 110743668
- Full Text :
- https://doi.org/10.1186/s12882-015-0172-8