Back to Search
Start Over
B7x: A widely expressed B7 family member that inhibits T cell activation.
- Source :
- Proceedings of the National Academy of Sciences of the United States of America; 9/2/2003, Vol. 100 Issue 18, p10388-10392, 5p, 2 Diagrams, 28 Graphs
- Publication Year :
- 2003
-
Abstract
- B7 family proteins provide costimulatory signals that regulate T cell responses. Here we report the third set of B7 family-related T cell inhibitory molecules with the identification of a homolog of the B7 family, B7x. It is expressed in immune cells, nonlymphoid tissues, and some tumor cell lines. BTx inhibits cell-cycle progression, proliferation, and cytokine production of both CD4[sup +] and CD8[sup +] T cells. BTx binds a receptor that is expressed on activated, but not resting T cells that is distinct from known CD28 family members. Its receptor may be a recently identified inhibitory molecule, B and T lymphocyte attenuator. These studies identify a costimulatory pathway that may have a unique function in down-regulation of tissue-specific autoimmunity and antitumor responses. [ABSTRACT FROM AUTHOR]
- Subjects :
- T cells
CELL receptors
CELLULAR control mechanisms
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 100
- Issue :
- 18
- Database :
- Complementary Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 11105762
- Full Text :
- https://doi.org/10.1073/pnas.1434299100