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Prevalence of drug resistant TB among outpatients at an HIV/TB clinic in Lilongwe, Malawi.
- Source :
- Transactions of the Royal Society of Tropical Medicine & Hygiene; Dec2015, Vol. 109 Issue 12, p763-768, 6p
- Publication Year :
- 2015
-
Abstract
- Background: We sought to determine the prevalence of drug resistant TB among outpatients initiating TB treatment in Lilongwe, Malawi. Methods: This was a prospective cohort study of patients 18 years and older initiating TB treatment at Martin Preuss Centre, the primary integrated HIV/TB clinic in Lilongwe, Malawi, from April 2011 to July 2012. Procedures included questionnaires, physical exam, chest x-ray, full blood count and sputum collection. Sputum samples underwent acid-fast bacilli (AFB) smear testing and culture by Lowenstein-Jensen (LJ) and liquid Mycobacteria Growth Indicator Tube (MGIT) methods. Drug sensitivity was investigated using the Hain GenoType MTBDRplus line probe assay. Results: Of the 702 patients, 219 (31.2%) were female and 653 (93.0%) were presenting for first-time TB treatment. HIV co-infection was present in 420 (59.8%) cases, with 137 (32.6%) of those patients receiving antiretroviral therapy at presentation. TB was culture-confirmed in 375 (53.4%) patients, 349 of which were first time treatment and 26 retreatment. Ten cases of isoniazid-resistant TB (2.9% of culture confirmed cases of newly treated TB), one of rifampin-resistant TB (0.3% culture confirmed cases of newly treated TB) and one of multi-drug resistant TB (MDR-TB) (3.8% of culture confirmed cases of retreatment TB) were detected. Conclusions: MDR-TB prevalence is low among outpatients initiating TB treatment in Lilongwe. [ABSTRACT FROM AUTHOR]
- Subjects :
- MULTIDRUG resistance
RIFAMPIN
TUBERCULOSIS treatment
OUTPATIENT medical care
CLINICS
Subjects
Details
- Language :
- English
- ISSN :
- 00359203
- Volume :
- 109
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- Transactions of the Royal Society of Tropical Medicine & Hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 111354580
- Full Text :
- https://doi.org/10.1093/trstmh/trv092