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Alternation in lipid kinetics in men with HIV-dyslipidemia.
- Source :
- American Journal of Physiology: Endocrinology & Metabolism; Sep2003, Vol. 48 Issue 3, pE490-E497, 8p, 3 Charts, 2 Graphs
- Publication Year :
- 2003
-
Abstract
- Hypertriglyceridemia is common in individuals with human immunodeficiency (HIV) infection, but the mechanisms responsible for increased plasma triglyceride (TG) concentrations are not clear. We evaluated fatty acid and VLDL-TG kinetics during basal conditions and during a glucose infusion that resulted in typical postprandial plasma glucose and insulin concentrations in six men with HIV-dyslipidemia [body mass index (BMI): 28 ± 2 kg/m²] and six healthy men (BMI: 26 ± 2 kg/m²). VLDL-TG secretion and palmitate rate of appearance (R[sub a]) in plasma were measured by using stable-isotope-labeled tracer techniques. Basal palmitate R[sub a] and VLDL-TG secretion rates were greater (P < 0.01 for both) in men with HIV-dyslipidemia (1.04 ± 0.07 µmol palmitate·kg[sup -1]·.min[sup -1] and 5.7 ± 0.6 µmol VLDL-TG·1 plasma[sup -1]·min[sup -1]) than in healthy men (0.67 ± 0.08 µmol palmitate·kg[sup -1]·min[sup -1] and 3.0 ± 0.5 µmol VLDL-TG·1 plasma[sup -1]·main[sup -1]). Basal VLDL-TG plasma clearance was lower in men with HIV dyslipidemia (13 ± 1 ml/min) than in healthy men (19 ± 2 ml/min; P < 0.05). Glucose infusion decreased palmitate R[sub a] (by ∼50%) and the VLDL-TG secretion rate (by ∼30%) in both groups, but the VLDL-TG secretion rate remained higher (P < 0.05) in subjects with HIV-dyslipidemia. These findings demonstrate that increased secretion of VLDL-TG and decreased plasma VLDL-TG clearance, during both fasting and fed conditions, contribute to hypertriglyceridemia in men with HIV-dyslipidemia. Although it is likely that increased free fatty acid release from adipose tissue contributes to the increase in basal VLDL-TG concentration, other factors must be involved, because insulin-induced suppression of lipolysis and systemic fatty acid availability did not normalize the VLDL-TG secretion rate. [ABSTRACT FROM AUTHOR]
- Subjects :
- LIPIDS
HYPERTRIGLYCERIDEMIA
Subjects
Details
- Language :
- English
- ISSN :
- 01931849
- Volume :
- 48
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- American Journal of Physiology: Endocrinology & Metabolism
- Publication Type :
- Academic Journal
- Accession number :
- 11149725
- Full Text :
- https://doi.org/10.1152/ajpendo.00118.2003