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Targeting IgE in Severe Atopic Dermatitis with a Combination of Immunoadsorption and Omalizumab.
- Source :
- Acta Dermato-Venereologica; Jan2016, Vol. 96 Issue 1, p72-76, 5p
- Publication Year :
- 2016
-
Abstract
- Patients with atopic dermatitis (AD) tend to have greatly elevated levels of serum immunoglobulin E (IgE). However, the role of IgE in the pathogenesis of AD is debated. This investigator-initiated open-label pilot study evaluates an anti-IgE-treatment approach by combining extracorporeal immunoadsorption and anti-IgE antibody omalizumab in 10 patients with severe, therapy-refractory AD. IgE levels decreased after immunoadsorption and decreased continuously in all patients during anti- IgE therapy. The reverse trend was observed during 6 months follow-up without treatment. In parallel with these observations, an improvement in AD was observed during the treatment period, with aggravation during follow-up. Further research is needed, based on the principle of reducing IgE levels in order to improve clinical symptoms, using a combination anti-IgE treatment approach, adjusted according to IgE levels. [ABSTRACT FROM AUTHOR]
- Subjects :
- IMMUNOGLOBULIN E
ATOPIC dermatitis
IMMUNOADSORPTION
SERUM
SYMPTOMS
Subjects
Details
- Language :
- English
- ISSN :
- 00015555
- Volume :
- 96
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Acta Dermato-Venereologica
- Publication Type :
- Academic Journal
- Accession number :
- 111972495
- Full Text :
- https://doi.org/10.2340/00015555-2165