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The Safety Evaluation of Salvianolic Acid B and Ginsenoside Rg1 Combination on Mice.
- Source :
- International Journal of Molecular Sciences; 2015, Vol. 16 Issue 12, p29345-29356, 13p, 2 Color Photographs, 1 Diagram, 6 Charts, 3 Graphs
- Publication Year :
- 2015
-
Abstract
- Our previous study indicated that the combination of salvianolic acid B (SalB) and ginsenoside Rg1 (Rg1), the main components of Salvia miltiorrhizae and Panax notoginseng, improves myocardium structure and ventricular function in rats with ischemia/reperfusion injury. The present study aimed to determine the safety of the combined SalB and Rg1 (SalB-Rg1) in mice. The safety of SalB-Rg1 was evaluated through acute toxicity and repeated-dose toxicity. In the acute toxicity study, the up and down procedure was carried out firstly, and then, the Bliss method was applied. In the toxicity study for seven-day repeated treatment of SalB-Rg1, forty Kunming mice were randomly divided into four groups. The intravenous median lethal dose (LD<subscript>50</subscript>) of the SalB-Rg1 combination was 1747 mg/kg using the Bliss method. For both the acute toxicity study and the seven-day repeated toxicity study, SalB-Rg1 did not induce significant abnormality on brain, heart, kidney, liver and lung structure at any dose based on H&E stain. There were no significant changes related to the SalB-Rg1 toxicity detected on biochemical parameters for two kinds of toxicity studies. The LD<subscript>50</subscript> in mice was 1747 mg/kg, which was more than one hundred times higher than the effective dose. Both studies of acute toxicity and seven-day repeated dose toxicity indicated the safety of the SalB-Rg1 combination. [ABSTRACT FROM AUTHOR]
- Subjects :
- GINSENOSIDES
ACID research
MYOCARDIAL reperfusion
LABORATORY mice
MEDICATION safety
Subjects
Details
- Language :
- English
- ISSN :
- 16616596
- Volume :
- 16
- Issue :
- 12
- Database :
- Complementary Index
- Journal :
- International Journal of Molecular Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 111988335
- Full Text :
- https://doi.org/10.3390/ijms161226176