Induction of HLA-B*40:02-restricted T cells possessing cytotoxic and suppressive functions against haematopoietic progenitor cells from a patient with severe aplastic anaemia.

The article offers information on a study concerning induction of human leucocyte antigen (HLA)-B restricted T cells possessing cytotoxic and suppressive functions against haematopoietic progenitor cells from a patient with severe aplastic anaemia. Topics discussed include treatment of acquired aplastic anaemia (AA) with antithymocyte globulin and ciclosporin (CsA), bone marrow (BM) hypoplasia and pancytopenia, and immune pressure of autoreactive cytotoxic T lymphocytes.