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Possible influence of AMPD1 on cholinergic neurotransmission and sleep.
- Source :
- Journal of Sleep Research; Feb2016, Vol. 25 Issue 1, p124-126, 3p
- Publication Year :
- 2016
-
Abstract
- It is known that adenosine excess due to monophosphate deaminase deficiency (AMPD1) can be linked to muscle problems. Recently, Perumal et al., 2014 reported a first case of possible impact of AMPD1 on sleep, REM sleep and cholinergic neurotransmission. We report a second patient with similar sleep complaints: long sleep duration with residual daytime sleepiness and a need to sleep after exercise. On polysomnography we observed a long sleep duration, with high sleep efficiency and a SOREMP; on MSLT a shortened sleep latency and 4 SOREMPS were observed. Frequency power spectral heart rate analysis during slow wave sleep, REM sleep and wakefulness revealed an increased parasympathetic tone. In conclusion, AMPD1 could have a profound influence on cholinergic neurotransmission and sleep; further studies are mandatory. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09621105
- Volume :
- 25
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Journal of Sleep Research
- Publication Type :
- Academic Journal
- Accession number :
- 112043382
- Full Text :
- https://doi.org/10.1111/jsr.12341