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Remote Ischemic Preconditioning May Attenuate Renal Ischemia-Reperfusion Injury in a Porcine Model of Supraceliac Aortic Cross-Clamping.
- Source :
- Journal of Vascular Research; Jan2016, Vol. 52 Issue 3, p161-171, 11p
- Publication Year :
- 2016
-
Abstract
- Aim: The effect of remote ischemic preconditioning (RIPC) in decreasing renal ischemia-reperfusion injury (IRI) during a suprarenal aortic cross-clamping was examined in a swine model. Materials and Methods: Four groups of pigs were examined: (a) ischemia-reperfusion (IR) group, renal IRI produced by 30 min of supraceliac aortic cross-clamping; (b) RIPC I group, the same renal IRI following RIPC by brief occlusion of the infrarenal aorta (15 min ischemia and 15 min reperfusion); (c) RIPC II group, the same renal IRI following RIPC by brief occlusion of the infrarenal aorta (3 cycles of 5 min ischemia and 5 min reperfusion); (d) sham group. Renal function was assessed before and after IRI by examining creatinine, neutrophil gelatinase-associated lipocalin (NGAL), TNF-α, malondialdehyde (MDA), cystatin C and C-reactive protein (CRP) from renal vein blood samples at specific time intervals. Results: Both RIPC groups presented significantly less impaired results compared to the IR group when considering MDA, cystatin C, CRP and creatinine. Between the two RIPC groups, RIPC II presented a better response with regard to CRP, NGAL, TNF-α, MDA and cystatin C. Conclusions: Remote IR protocols and mainly repetitive short periods of cycles of IR ameliorate the biochemical kidney effects of IRI in a model of suprarenal aortic aneurysm repair. © 2015 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Subjects :
- ISCHEMIA
REPERFUSION
LIPOCALINS
CREATININE
MALONDIALDEHYDE
Subjects
Details
- Language :
- English
- ISSN :
- 10181172
- Volume :
- 52
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Vascular Research
- Publication Type :
- Academic Journal
- Accession number :
- 112144990
- Full Text :
- https://doi.org/10.1159/000439219