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Interleukin 10 and dendritic cells are the main suppression mediators of regulatory T cells in human neurocysticercosis.
- Source :
- Clinical & Experimental Immunology; Feb2016, Vol. 183 Issue 2, p271-279, 9p, 3 Charts, 3 Graphs
- Publication Year :
- 2016
-
Abstract
- Neurocysticercosis is caused by the establishment of Taenia solium cysticerci in the central nervous system. It is considered that, during co-evolution, the parasite developed strategies to modulate the host's immune response. The action mechanisms of regulatory T cells in controlling the immune response in neurocysticercosis are studied in this work. Higher blood levels of regulatory T cells with CD4<superscript>+</superscript>CD45RO<superscript>+</superscript>forkhead box protein 3 (FoxP3)<superscript>high</superscript> and CD4<superscript>+</superscript>CD25<superscript>high</superscript>FoxP3<superscript>+</superscript>CD95<superscript>high</superscript> phenotype and of non-regulatory CD4<superscript>+</superscript>CD45RO<superscript>+</superscript>FoxP3<superscript>med</superscript> T cells were found in neurocysticercosis patients with respect to controls. Interestingly, regulatory T cells express higher levels of cytotoxic T lymphocyte antigen 4 (CTLA-4), lymphocyte-activation gene 3 (LAG-3), programmed death 1 (PD-1) and glucocorticoid-induced tumour necrosis factor receptor (GITR), suggesting a cell-to-cell contact mechanism with dendritic cells. Furthermore, higher IL-10 and regulatory T cell type 1 (Tr1) levels were found in neurocysticercosis patients' peripheral blood, suggesting that the action mechanism of regulatory T cells involves the release of immunomodulatory cytokines. No evidence was found of the regulatory T cell role in inhibiting the proliferative response. Suppressive regulatory T cells from neurocysticercosis patients correlated negatively with late activated lymphocytes (CD4<superscript>+</superscript>CD38<superscript>+</superscript>). Our results suggest that, during neurocysticercosis, regulatory T cells could control the immune response, probably by a cell-to-cell contact with dendritic cells and interleukin (IL)-10 release by Tr1, to create an immunomodulatory environment that may favour the development of T. solium cysticerci and their permanence in the central nervous system. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00099104
- Volume :
- 183
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Clinical & Experimental Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 112233655
- Full Text :
- https://doi.org/10.1111/cei.12709