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Orally delivered microencapsulated probiotic formulation favorably impacts polyp formation in APC (Min/+) model of intestinal carcinogenesis.
- Source :
- Artificial Cells, Nanomedicine & Biotechnology; Feb2016, Vol. 44 Issue 1, p1-11, 11p
- Publication Year :
- 2016
-
Abstract
- The development of intestinal polyps in an orthotopic colorectal mouse model, receiving a probiotic yogurt formulation containing microencapsulated liveLactobacillus acidophiluscells was investigated. The expression of various immunohistochemical markers namely CD8, Mac-1, Ki-67, and cleaved caspase-3, was evaluated. Results suggest that the probiotic formulation decreases overall intestinal inflammation. Mice receiving the probiotic formulation were found to develop almost two-fold fewer tumors in the small intestines. In the large intestine, however, there was no significant difference observed among polyp numbers. The formulation appears to have potential application in the prevention of various GI pathological conditions. [ABSTRACT FROM PUBLISHER]
- Subjects :
- CARCINOGENICITY
PETO'S paradox
POLYPS
CARCINOGENESIS
INTESTINAL diseases
Subjects
Details
- Language :
- English
- ISSN :
- 21691401
- Volume :
- 44
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Artificial Cells, Nanomedicine & Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 112233773
- Full Text :
- https://doi.org/10.3109/21691401.2014.898647