Back to Search Start Over

Cancer in World Trade Center responders: Findings from multiple cohorts and options for future study.

Authors :
Boffetta, Paolo
Zeig‐Owens, Rachel
Wallenstein, Sylvan
Li, Jiehui
Brackbill, Robert
Cone, James
Farfel, Mark
Holden, William
Lucchini, Roberto
Webber, Mayris P.
Prezant, David
Stellman, Steven D.
Source :
American Journal of Industrial Medicine; Feb2016, Vol. 59 Issue 2, p96-105, 10p
Publication Year :
2016

Abstract

Background Three longitudinal studies of cancer incidence in varied populations of World Trade Center responders have been conducted. Methods We compared the design and results of the three studies. Results Separate analyses of these cohorts revealed excess cancer incidence in responders for all cancers combined and for cancers of the thyroid and prostate. Methodological dissimilarities included recruitment strategies, source of cohort members, demographic characteristics, overlap between cohorts, assessment of WTC and other occupational exposures and confounders, methods and duration of follow-up, approaches for statistical analysis, and latency analyses. Conclusions The presence of three cohorts strengthens the effort of identifying and quantifying the cancer risk; the heterogeneity in design might increase sensitivity to the identification of cancers potentially associated with exposure. The presence and magnitude of an increased cancer risk remains to be fully elucidated. Continued long-term follow up with minimal longitudinal dropout is crucial to achieve this goal. Am. J. Ind. Med. 59:96-105, 2015. © 2015 Wiley Periodicals, Inc. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
02713586
Volume :
59
Issue :
2
Database :
Complementary Index
Journal :
American Journal of Industrial Medicine
Publication Type :
Academic Journal
Accession number :
112262115
Full Text :
https://doi.org/10.1002/ajim.22555