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Benzothiazole-Pyimidine-Based BF2 Complex for Selective Detection of Cysteine.
- Source :
- Chemistry - An Asian Journal; Jan2016, Vol. 11 Issue 2, p202-206, 5p
- Publication Year :
- 2016
-
Abstract
- Due to the similar structure and reactivity of cysteine (Cys), homocysteine (Hcy) and glutathione (GSH), the simultaneous discrimination of Cys over Hcy and GSH by a single fluorescent sensor is still a great challenge. In this work, a benzothiazole-pyimidine-based boron difluoride complex ( BPB) was developed as a new fluorescent sensor for Cys. The sensor exhibits a highly selective 'turn-on' response to cysteine over Hcy, GSH and other amino acids in aqueous solution at physiological pH. The observed pseudo-first-order rate constant for the reaction of BPB with Cys was calculated to be about 0.062 min<superscript>−1</superscript>. The detection limit of this sensor for Cys was determined to be 332 n m, and bioimaging of exogenous Cys by this sensor was successfully applied in living cells, thus indicating that this sensor holds great potential for biological applications. [ABSTRACT FROM AUTHOR]
- Subjects :
- CYSTEINE
HOMOCYSTEINE
GLUTATHIONE
BORON compounds
FLUORESCENT probes
Subjects
Details
- Language :
- English
- ISSN :
- 18614728
- Volume :
- 11
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Chemistry - An Asian Journal
- Publication Type :
- Academic Journal
- Accession number :
- 112506831
- Full Text :
- https://doi.org/10.1002/asia.201501013