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Transcriptional Analysis of T Cells Resident in Human Skin.
- Source :
- PLoS ONE; 1/29/2016, Vol. 11 Issue 1, p1-16, 16p
- Publication Year :
- 2016
-
Abstract
- Human skin contains various populations of memory T cells in permanent residence and in transit. Arguably, the best characterized of the skin subsets are the CD8<superscript>+</superscript> permanently resident memory T cells (T<subscript>RM</subscript>) expressing the integrin subunit, CD103. In order to investigate the remaining skin T cells, we isolated skin-tropic (CLA<superscript>+</superscript>) helper T cells, regulatory T cells, and CD8<superscript>+</superscript> CD103<superscript>-</superscript> T cells from skin and blood for RNA microarray analysis to compare the transcriptional profiles of these groups. We found that despite their common tropism, the T cells isolated from skin were transcriptionally distinct from blood-derived CLA<superscript>+</superscript> T cells. A shared pool of genes contributed to the skin/blood discrepancy, with substantial overlap in differentially expressed genes between each T cell subset. Gene set enrichment analysis further showed that the differential gene profiles of each human skin T cell subset were significantly enriched for previously identified T<subscript>RM</subscript> core signature genes. Our results support the hypothesis that human skin may contain additional T<subscript>RM</subscript> or T<subscript>RM</subscript>-like populations. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 112634235
- Full Text :
- https://doi.org/10.1371/journal.pone.0148351