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A dose-response study of vitamin D3 supplementation in healthy Chinese: a 5-arm randomized, placebo-controlled trial.
- Source :
- European Journal of Nutrition; Feb2016, Vol. 55 Issue 1, p383-392, 10p
- Publication Year :
- 2016
-
Abstract
- Purpose: To determine the dose-response of vitamin D3 supplementation on serum 25-hydroxyvitamin D [25(OH)D] among Chinese adults. Methods: In this 5-arm, randomized, double-blinded controlled trial, 76 healthy participants were assigned to orally administrate 0, 400, 800, 1200 or 2000 IU/d of vitamin D3 for 16 weeks. Serum 25(OH)D, parathyroid hormone, calcium, biomarkers of liver and renal function were measured at multiple time points. Results: The mean (SD) serum 25(OH)D at baseline was 31.6 (8.7) nmol/L, and the dose-response relationship was curvilinear with a plateau around 6 weeks for all doses. At week 16, 25(OH)D was increased by 6.0 (6.5), 21.7 (15.8), 26.3 (12.6), 32.0 (12.8) and 36.3 (26.0) nmol/L for 0, 400, 800, 1200 and 2000 IU/d (all P ≤ 0.002), corresponding to approximately 19, 53, 67, 77 and 80 % of reversion of vitamin D deficiency, respectively. Daily intake of 800 IU vitamin D3 reached a targeted 25(OH)D ≥ 30 nmol/L in at least 97.5 % of Chinese, but not a targeted 25(OH)D ≥ 50 nmol/L even with 2000 IU/d. Change of 25(OH)D was inversely associated with change of PTH concentration ( r = −0.39, P < 0.001) after controlling for age and sex. No between-group differences were observed in terms of the change in serum calcium, alanine transaminase, aspartate aminotransferase, gamma-glutamyltransferase and creatinine ( P ≥ 0.22). Conclusions: Supplementation with 400, 800, 1200 or 2000 IU/d vitamin D could improve the vitamin D deficiency with various degrees. Whether 2000 IU/d vitamin D3 would generate a better result without side effect requires more studies with larger samples in future. [ABSTRACT FROM AUTHOR]
- Subjects :
- VITAMIN D deficiency
ANALYSIS of covariance
ANALYSIS of variance
CALCIUM
CHINESE people
DIETARY supplements
DOSE-effect relationship in pharmacology
FISHER exact test
INTERVIEWING
KIDNEY function tests
LIVER function tests
LONGITUDINAL method
NUTRITIONAL assessment
ORAL drug administration
PARATHYROID hormone
PROBABILITY theory
QUESTIONNAIRES
RESEARCH funding
STATISTICAL sampling
STATISTICAL hypothesis testing
STATISTICS
VITAMIN D
DATA analysis
MULTIPLE regression analysis
CHOLECALCIFEROL
BODY mass index
LIFESTYLES
RANDOMIZED controlled trials
BLIND experiment
FOOD diaries
PHYSICAL activity
DATA analysis software
DESCRIPTIVE statistics
KRUSKAL-Wallis Test
PREVENTION
Subjects
Details
- Language :
- English
- ISSN :
- 14366207
- Volume :
- 55
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- European Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 112692615
- Full Text :
- https://doi.org/10.1007/s00394-015-0859-4