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Photothermal cancer therapy by gold-ferrite nanocomposite and near-infrared laser in animal model.
- Source :
- Lasers in Medical Science; Feb2016, Vol. 31 Issue 2, p221-227, 7p
- Publication Year :
- 2016
-
Abstract
- Surface plasmon resonance effect of gold nanostructures makes them good candidates for photothermal therapy (PTT) application. Herein, gold-ferrite nanocomposite (GFNC) was synthesized and characterized as a photothermal agent in PTT. The aim of this study was to investigate the effect of GFNC upon laser irradiation on treatment of cancer in mice bearing melanoma cancer. Thirty mice received 1.5 × 10(6) B16/F10 cells subcutaneously. After 1 week, the mice bearing solid tumor were divided into four groups: control group (without any treatment), laser group (received laser irradiation without GFNC injection), GFNC group (only received intratumorally GFNC), and GFNC + laser group (received intratumorally GFNC upon laser irradiation). In GFNC + laser group, 200 μL of fluid, 1.3 × 10(-7) mol L(-1) gold nanoparticles, was injected intratumorally and immediately the site of tumor was exposed to continuous wave diode laser beam (808 nm, 1.6 W cm(-2)) for 15 min. All mice but four were euthanized 24 h after treatment to compare the necrotic surface area histologically by using measuring graticule. Statistical analyses revealed significant differences in necrosis extent for GFNC + laser group, compared to other groups. Four subjects (control group and GFNC + laser group, two mice each) were kept for longitudinal study. Histological analyses and tumor volume measurements of the four subjects indicated that tumor in GFNC + laser group was controlled appropriately. It was concluded that combining an 808-nm laser at a power density of 1.6 W cm(-2) with GFNC has a destruction effect in melanoma cancer cells in an animal model. [ABSTRACT FROM AUTHOR]
- Subjects :
- PHOTOTHERMAL effect
CANCER treatment
FERRITES
GOLD nanoparticles
NEAR infrared radiation
ANIMAL models in research
MELANOMA treatment
THERAPEUTIC nanotechnology
NONIONIZING radiation
ANIMAL experimentation
BIOLOGICAL models
CELL lines
COMBINED modality therapy
GOLD
IRON compounds
MEDICAL lasers
MELANOMA
MICE
NANOPARTICLES
NANOTECHNOLOGY
THERAPEUTICS
Subjects
Details
- Language :
- English
- ISSN :
- 02688921
- Volume :
- 31
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Lasers in Medical Science
- Publication Type :
- Academic Journal
- Accession number :
- 112694168
- Full Text :
- https://doi.org/10.1007/s10103-015-1847-x