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Photocytotoxicity and G-quadruplex DNA interaction of water-soluble gallium(III) tris( N-methyl-4-pyridyl)corrole complex.
- Source :
- Applied Organometallic Chemistry; Mar2016, Vol. 30 Issue 3, p132-139, 8p
- Publication Year :
- 2016
-
Abstract
- A water-soluble cationic gallium corrole, 5,10,15-tris( N-methyl-4-pyridyl)corrolatogallium(III) ( 3), was prepared and characterized. The photocytotoxicity of 3 was investigated using Hep G2 cancer cell line. Upon treatment with corrole 3 and irradiation, of tumor cell nuclei was observed, which led to apoptosis. Flow cytometric analysis clearly showed the efficient induction of apoptotic cell death, and corrole 3 exhibited high photocytotoxicity towards Hep G2 cancer cells (IC<subscript>50</subscript> = 60 nM). Furthermore, the binding behavior of corrole 3 with c-MYC G-quadruplex DNA, a potent target for antitumor drugs, was investigated using spectroscopic methods and molecular docking simulation. Copyright © 2015 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 02682605
- Volume :
- 30
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Applied Organometallic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 112710382
- Full Text :
- https://doi.org/10.1002/aoc.3408