Back to Search
Start Over
Reversibility of β-Cell-Specific Transcript Factors Expression by Long-Term Caloric Restriction in db/db Mouse.
- Source :
- Journal of Diabetes Research; 2/21/2016, p1-11, 11p
- Publication Year :
- 2016
-
Abstract
- Type 2 diabetes (T2D) is characterized by β-cell dedifferentiation, but underlying mechanisms remain unclear. The purpose of the current study was to explore the mechanisms of β-cell dedifferentiation with and without long-term control of calorie intake. We used a diabetes mouse model (db/db) to analyze the changes in the expression levels of β-cell-specific transcription factors (TFs) and functional factors with long-term caloric restriction (CR). Our results showed that chronic euglycemia was maintained in the db/db mice with long-term CR intervention, and β-cell dedifferentiation was significantly reduced. The expression of Glut2, Pdx1, and Nkx6.1 was reversed, while MafA expression was significantly increased with long-term CR. GLP-1 pathway was reactivated with long-term CR. Our work showed that the course of β-cell dedifferentiation can intervene by long-term control of calorie intake. Key β-cell-specific TFs and functional factors play important roles in maintaining β-cell differentiation. Targeting these factors could optimize T2D therapies. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 23146745
- Database :
- Complementary Index
- Journal :
- Journal of Diabetes Research
- Publication Type :
- Academic Journal
- Accession number :
- 113196809
- Full Text :
- https://doi.org/10.1155/2016/6035046