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A scalable and facile process for the preparation of N-(pyridin-4-yl) piperazine-1-carboxamide hydrochloride.
- Source :
- Journal of Chemical Research; Mar2016, Vol. 40 Issue 3, p152-155, 4p
- Publication Year :
- 2016
-
Abstract
- A scalable and facile synthetic process for N-(pyridin-4-yl)piperazine-1-carboxamide hydrochloride, a novel Rho kinase inhibitor with an unsymmetrical urea structure currently under investigation for the treatment of central nervous system disorders, was established. After optimisation of the reaction conditions, N-(pyridin-4-yl)piperazine-1-carboxamide hydrochloride was synthesised from 4-aminopyridine and N,N'-carbonyldiimidazole through acylation, deprotection and salt formation. This new procedure affords the product in 53% overall yield with high purity and it can be easily scaled up for production. [ABSTRACT FROM AUTHOR]
- Subjects :
- PIPERAZINE
KINASE inhibitors
ACYLATION
AMINOPYRIDINES
CHEMICAL synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 17475198
- Volume :
- 40
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Chemical Research
- Publication Type :
- Academic Journal
- Accession number :
- 113542267
- Full Text :
- https://doi.org/10.3184/174751916X14546711471143