Back to Search
Start Over
Novel dibenzo-18-crown-6 ether functionalized bis-benzimidazole derivatives: synthesis and antifungal evaluation.
- Source :
- Research on Chemical Intermediates; Mar2016, Vol. 42 Issue 3, p2449-2459, 11p, 2 Black and White Photographs, 2 Diagrams, 3 Charts
- Publication Year :
- 2016
-
Abstract
- A series of novel 18-crown-6 ether functionalized bis-benzimidazole derivatives ( 3a- g) have been synthesized by reacting various substituted ortho-phenylene diamines and pyridine diamines with 4,4′-diformyl dibenzo-18-crown-6 ether ( 1). The required starting material 4,4′-diformyl dibenzo-18-crown-6 ether ( 1) was prepared by Duff formylation method. All synthesized novel molecules have been identified on the basis of infrared (IR), H nuclear magnetic resonance (NMR), C NMR, mass spectroscopy (MS), and elemental analyses. The title compounds ( 3a- g) were tested for antifungal activity against Aspergillus niger, Trichothecium sp., Rhizopus sp., and Sclerotium rolfsii fungi species using agar well diffusion method, showing mild to good results. Graphical abstract: [Figure not available: see fulltext.] [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09226168
- Volume :
- 42
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Research on Chemical Intermediates
- Publication Type :
- Academic Journal
- Accession number :
- 113545588
- Full Text :
- https://doi.org/10.1007/s11164-015-2160-9