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Supramolecular Encapsulation of Vitamin B6 by Macrocyclic Nanocontainer Cucurbit[7]uril.
- Source :
- Journal of Nanomaterials; 11/18/2015, p1-6, 6p
- Publication Year :
- 2015
-
Abstract
- A pharmaceutically and biologically relevant molecule, pyridoxine hydrochloride (vitamin B<subscript>6</subscript>), was encapsulated inside the cavity of a molecular container, cucurbit[7]uril (CB[7]), in aqueous solution. The CB[7] based “nanocapsule” of vitamin B<subscript>6</subscript> has been investigated for the first time, via <superscript>1</superscript>H NMR and UV-visible spectroscopic titrations (including Job’s plot) and ab initio molecular modeling. The results have demonstrated that vitamin B<subscript>6</subscript> forms stable host-guest complexes within CB[7] in 1 : 1 stoichiometry, with a binding affinity of (4.0±0.5)×<superscript>10</superscript><superscript>3</superscript> M<superscript>−1</superscript>. Such a nanocapsule could potentially find application in vitamin B<subscript>6</subscript> formulation for the purpose of enhancing the stability, absorption, and delivery of this important vitamin. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16874110
- Database :
- Complementary Index
- Journal :
- Journal of Nanomaterials
- Publication Type :
- Academic Journal
- Accession number :
- 113599254
- Full Text :
- https://doi.org/10.1155/2015/574013