Back to Search
Start Over
A CMOS Amperometric System for Multi-Neurotransmitter Detection.
- Source :
- IEEE Transactions on Biomedical Circuits & Systems; Jun2016, Vol. 10 Issue 3, p731-741, 11p
- Publication Year :
- 2016
-
Abstract
- In vivo multi-target and selective concentration monitoring of neurotransmitters can help to unravel the brain chemical complex signaling interplay. This paper presents a dedicated integrated potentiostat transducer circuit and its selective electrode interface. A custom 2-electrode time-based potentiostat circuit was fabricated with 0.13 \mum CMOS technology and provides a wide dynamic input current range of 20 pA to 600 nA with 56 \muW, for a minimum sampling frequency of 1.25 kHz. A multi-working electrode chip is functionalized with carbon nanotubes (CNT)-based chemical coatings that offer high sensitivity and selectivity towards electroactive dopamine and non-electroactive glutamate. The prototype was experimentally tested with different concentrations levels of both neurotransmitter types, and results were similar to measurements with a commercially available potentiostat. This paper validates the functionality of the proposed biosensor, and demonstrates its potential for the selective detection of a large number of neurochemicals. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 19324545
- Volume :
- 10
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- IEEE Transactions on Biomedical Circuits & Systems
- Publication Type :
- Academic Journal
- Accession number :
- 113814006
- Full Text :
- https://doi.org/10.1109/TBCAS.2015.2490225