Global copy number profiling of cancer genomes.

Summary: In this article, we introduce a robust and efficient strategy for deriving global and allelespecific copy number alternations (CNA) from cancer whole exome sequencing data based on Log R ratios and B-allele frequencies. Applying the approach to the analysis of over 200 skin cancer samples, we demonstrate its utility for discovering distinct CNA events and for deriving ancillary information such as tumor purity. [ABSTRACT FROM AUTHOR]