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1-[4-Fluoro-2-(2-nitrovinyl)phenyl]pyrrolidine Suppresses Toll-Like Receptor 4 Dimerization Induced by Lipopolysaccharide.
- Source :
- Journal of Immunoassay & Immunochemistry; 2016, Vol. 37 Issue 3, p307-315, 9p
- Publication Year :
- 2016
-
Abstract
- Toll-like receptor 4 (TLR4) recognizes LPS and triggers the activation of the myeloid differential factor 88 (MyD88)- and toll-interleukin-1 receptor domain-containing adapter, inducing interferon-β (TRIF)-dependent major downstream signaling pathways. Previously, we presented biochemical evidence that 1-[4-Fluoro-2-(2-nitrovinyl)phenyl]pyrrolidine (FPP), which was synthesized in our laboratory, inhibits NF-κB activation induced by LPS. Here, we investigated whether FPP modulates the TLR4 downstream signaling pathways and what anti-inflammatory target in TLR4 signaling is regulated by FPP. FPP inhibited LPS-induced NF-κB activation by targeting TLR4 dimerization. These results suggest that FPP can modulate the TLR4 signaling pathway at the receptor level to decrease inflammatory gene expression. [ABSTRACT FROM PUBLISHER]
Details
- Language :
- English
- ISSN :
- 15321819
- Volume :
- 37
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- Journal of Immunoassay & Immunochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 114193566
- Full Text :
- https://doi.org/10.1080/15321819.2015.1135162