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KLF2 is downregulated in pancreatic ductal adenocarcinoma and inhibits the growth and migration of cancer cells.

Authors :
Zhang, Dexiang
Dai, Yuedi
Cai, Yuankun
Suo, Tao
Liu, Han
Wang, Yueqi
Cheng, Zhijian
Liu, Houbao
Source :
Tumor Biology (Springer Science & Business Media B.V.); Mar2016, Vol. 37 Issue 3, p3425-3431, 7p
Publication Year :
2016

Abstract

Members of the Kruppel-like factor (KLF) family have been considered as the tumor suppressors for their inhibitory effects on cell proliferation. Dysregulation of KLF2, a member of KLF family, has been observed in various cancer types. However, its expression pattern and functions in the pancreatic ductal adenocarcinoma (PDAC) are unknown. In this study, we examined the expression of KLF2 in PDAC clinical samples and evaluated the functions of KLF2 in the progression of PDAC. KLF2 is shown to be downregulated in PDAC clinical samples and overexpression of KLF2 inhibits the growth, migration, and metastasis of PDAC cancer cells. KLF2 interacts with beta-catenin and negatively regulates the beta-catenin/TCF signaling. Taken together, this study suggests the suppressive functions of KLF2 in PDAC. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10104283
Volume :
37
Issue :
3
Database :
Complementary Index
Journal :
Tumor Biology (Springer Science & Business Media B.V.)
Publication Type :
Academic Journal
Accession number :
114817948
Full Text :
https://doi.org/10.1007/s13277-015-4053-3