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Upregulation of MALAT-1 and its association with survival rate and the effect on cell cycle and migration in patients with esophageal squamous cell carcinoma.

Authors :
Yao, Wenjian
Bai, Yu
Li, Yan
Guo, Ling
Zeng, Ping
Wang, Yonglian
Qi, Bo
Liu, Shangguo
Qin, Xiuguang
Li, Yongzhen
Zhao, Baosheng
Source :
Tumor Biology (Springer Science & Business Media B.V.); Apr2016, Vol. 37 Issue 4, p4305-4312, 8p
Publication Year :
2016

Abstract

The aim of this study is to investigate whether metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) can be used as a potential therapy target for human esophageal squamous cell carcinoma. MALAT-1 expression levels were detected in 137 paired EC samples and adjacent nonneoplastic tissues. Human esophageal carcinoma cell lines EC9706 and KYSE150 were transfected with MALAT-1 small interference RNA. Cell proliferation, migration/invasion ability, cell cycle, and apoptosis were assessed. MALAT-1 expressed higher levels in esophageal cancer tissues when compared with paired adjacent normal tissues. This high expression was associated with a decreased survival rate. MALAT-1 knockdown induced a decrease in proliferation-enhanced apoptosis, inhibited migration/invasion, and reduced colony formation and led to cell cycle arrest at the G2/M phase. These data indicates that MALAT-1 could be exploited for therapeutic benefit. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10104283
Volume :
37
Issue :
4
Database :
Complementary Index
Journal :
Tumor Biology (Springer Science & Business Media B.V.)
Publication Type :
Academic Journal
Accession number :
114818105
Full Text :
https://doi.org/10.1007/s13277-015-4223-3