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Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential.
- Source :
- PLoS ONE; 4/27/2016, Vol. 11 Issue 4, p1-22, 22p
- Publication Year :
- 2016
-
Abstract
- CD11c is an α integrin classically employed to define myeloid dendritic cells. Although there is little information about CD11c expression on human T cells, mouse models have shown an association of CD11c expression with functionally relevant T cell subsets. In the context of genital tract infection, we have previously observed increased expression of CD11c in circulating T cells from mice and women. Microarray analyses of activated effector T cells expressing CD11c derived from naïve mice demonstrated enrichment for natural killer (NK) associated genes. Here we find that murine CD11c<superscript>+</superscript> T cells analyzed by flow cytometry display markers associated with non-conventional T cell subsets, including γδ T cells and invariant natural killer T (iNKT) cells. However, in women, only γδ T cells and CD8<superscript>+</superscript> T cells were enriched within the CD11c fraction of blood and cervical tissue. These CD11c<superscript>+</superscript> cells were highly activated and had greater interferon (IFN)-γ secretory capacity than CD11c<superscript>-</superscript> T cells. Furthermore, circulating CD11c<superscript>+</superscript> T cells were associated with the expression of multiple adhesion molecules in women, suggesting that these cells have high tissue homing potential. These data suggest that CD11c expression distinguishes a population of circulating T cells during bacterial infection with innate capacity and mucosal homing potential. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- PLoS ONE
- Publication Type :
- Academic Journal
- Accession number :
- 114877564
- Full Text :
- https://doi.org/10.1371/journal.pone.0154253