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Preparation and Characterization of TPGS-Colloidal Silica Microparticles for Enhancement of Solubility and Oral Bioavailability of Lercanidipine Hydrochloride.
- Source :
- Bulletin of the Korean Chemical Society; May2016, Vol. 37 Issue 5, p660-666, 7p
- Publication Year :
- 2016
-
Abstract
- In this study, colloidal silica microparticles containing solubilizing excipient were prepared using the spray-drying process to enhance dissolution and oral absorption of lercanidipine hydrochloride. Several measurements including scanning electron microscopy, powder X-ray diffraction, particle size determination, in vitro dissolution, and pharmacokinetic study were conducted in rats. Among the tested solubilizing excipients, d-α-tocopheryl polyethylene glycol 1000 succinate ( TPGS) dramatically enhanced the solubility of lercanidipine hydrochloride through micelle solubilization. In addition, TPGS-colloidal silica microparticles at the ratio of 1:10:10 (drug: TPGS:colloidal silica) showed rapid dissolution rate in all dissolution media and displayed higher area under the curve and maximum plasma concentration values compared with raw lercanidipine hydrochloride. Therefore, amorphous TPGS-colloidal silica microparticles fabricated using the spray-drying process have great potential in the clinical application of lercanidipine hydrochloride. [ABSTRACT FROM AUTHOR]
- Subjects :
- SILICA nanoparticles
MICELLES synthesis
DISSOLUTION (Chemistry)
COLLOIDS
SUCCINATES
Subjects
Details
- Language :
- English
- ISSN :
- 02532964
- Volume :
- 37
- Issue :
- 5
- Database :
- Complementary Index
- Journal :
- Bulletin of the Korean Chemical Society
- Publication Type :
- Academic Journal
- Accession number :
- 115159339
- Full Text :
- https://doi.org/10.1002/bkcs.10746