Dosimetry of indigenously developed 192Ir high-dose rate brachytherapy source: An EGSnrc Monte Carlo study.

Clinical application using high-dose rate (HDR) ¹⁹²Ir sources in remote afterloading technique is a well-established treatment method. In this direction, Board of Radiation and Isotope Technology (BRIT) and Bhabha Atomic Research Centre, India, jointly indigenously developed a remote afterloading machine and ¹⁹²Ir HDR source. The two-dimensional (2D) dose distribution and dosimetric parameters of the BRIT ¹⁹²Ir HDR source are generated using EGSnrc Monte Carlo code system in a 40 cm dia X 40 cm height cylindrical water phantom. The values of air-kerma strength and dose rate constant for BRIT ¹⁹²Ir HDR source are 9.894 x 10^-8 ± 0.06% UBq^-1 and 1.112 ± 0.11% cGyh^-1U^-1, respectively. The values of radial dose function (g_L(r)) of this source compare well with the corresponding values of BEBIG, Flexisource, and GammaMed 12i source models. This is because of identical active lengths of the sources (3.5 mm) and the comparable phantom dimensions. A comparison of g_L(r) values of BRIT source with microSelectron-v1 show differences about 2% at r = 6 cm and up to 13% at r = 12 cm, which is due to differences in phantom dimensions involved in the calculations. The anisotropy function of BRIT ¹⁹²Ir HDR source is comparable with the corresponding values of microSelectron-v1 (classic) HDR source. [ABSTRACT FROM AUTHOR]