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Effects of Ganglioside on Working Memory and the Default Mode Network in Individuals with Subjective Cognitive Impairment: A Randomized Controlled Trial.
- Source :
- American Journal of Chinese Medicine; 2016, Vol. 44 Issue 3, p489-514, 26p, 1 Diagram, 7 Charts, 6 Graphs
- Publication Year :
- 2016
-
Abstract
- This randomized, double-blind, placebo-controlled trial examined whether the administration of ganglioside, an active ingredient of deer bone extract, can improve working memory performance by increasing gray matter volume and functional connectivity in the default mode network (DMN) in individuals with subjective cognitive impairment. Seventy-five individuals with subjective cognitive impairment were chosen to receive either ganglioside (330g/day or 660g/day) or a placebo for 8 weeks. Changes in working memory performance with treatment of either ganglioside or placebo were assessed as cognitive outcome measures. Using voxel-based morphometry and functional connectivity analyses, changes in gray matter volume and functional connectivity in the DMN were also assessed as brain outcome measures. Improvement in working memory performance was greater in the ganglioside group than in the placebo group. The ganglioside group, relative to the placebo group, showed greater increases in gray matter volume and functional connectivity in the DMN. A significant relationship between increased functional connectivity of the precuneus and improved working memory performance was observed in the ganglioside group. The current findings suggest that ganglioside has cognitive-enhancing effects in individuals with subjective cognitive impairment. Ganglioside-induced increases in gray matter volume and functional connectivity in the DMN may partly be responsible for the potential nootropic effects of ganglioside. The clinical trial was registered with ClinicalTrials.gov (identifier: NCT02379481). [ABSTRACT FROM AUTHOR]
- Subjects :
- ALTERNATIVE medicine
BONES
BRAIN
CHI-squared test
COGNITION disorders
STATISTICAL correlation
FISHER exact test
MAGNETIC resonance imaging
MAMMALS
NEUROPSYCHOLOGICAL tests
MEMORY
NEURAL conduction
ORAL drug administration
PROBABILITY theory
RESEARCH funding
STATISTICAL sampling
STATISTICAL hypothesis testing
T-test (Statistics)
RANDOMIZED controlled trials
PRE-tests & post-tests
BLIND experiment
DATA analysis software
DESCRIPTIVE statistics
GRAY matter (Nerve tissue)
Subjects
Details
- Language :
- English
- ISSN :
- 0192415X
- Volume :
- 44
- Issue :
- 3
- Database :
- Complementary Index
- Journal :
- American Journal of Chinese Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 115247789
- Full Text :
- https://doi.org/10.1142/S0192415X16500270