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A dose-response meta-analysis reveals an association between vitamin B12 and colorectal cancer risk.
- Source :
- Public Health Nutrition; Jun2016, Vol. 19 Issue 8, p1446-1456, 11p
- Publication Year :
- 2016
-
Abstract
- <bold>Objective: </bold>The current meta-analysis evaluated the association between vitamin B12 intake and blood vitamin B12 level and colorectal cancer (CRC) risk.<bold>Design: </bold>The PubMed and EMBASE databases were searched. A dose-response analysis was performed with generalized least squares regression, with the relative risk (RR) and 95 % CI as effect values.<bold>Setting: </bold>The meta-analysis included seventeen studies.<bold>Subjects: </bold>A total of 10 601 patients.<bold>Results: </bold>The non-linear dose-response relationship between total vitamin B12 intake and CRC risk was insignificant (P=0·690), but the relationship between dietary vitamin B12 intake and CRC risk was significant (P<0·001). Every 4·5 μg/d increment in total and dietary vitamin B12 intake was inversely associated with CRC risk (total intake: RR=0·963; 95 % CI 0·928, 0·999; dietary intake: RR=0·914; 95 % CI 0·856, 0·977). The inverse association between vitamin B12 intake and CRC risk was also significant when vitamin B12 intake was over a dosage threshold, enhancing the non-linear relationship. The non-linear dose-response relationship between blood vitamin B12 level and CRC risk was insignificant (P=0·219). There was an insignificant association between every 150 pmol/l increment in blood vitamin B12 level and CRC risk (RR=1·023; 95 % CI 0·881, 1·187).<bold>Conclusions: </bold>Our meta-analysis indicates that evidence supports the use of vitamin B12 for cancer prevention, especially among populations with high-dose vitamin B12 intake, and that the association between CRC risk and total vitamin B12 intake is stronger than between CRC risk and dietary vitamin B12 intake only. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13689800
- Volume :
- 19
- Issue :
- 8
- Database :
- Complementary Index
- Journal :
- Public Health Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 115251745
- Full Text :
- https://doi.org/10.1017/S136898001500261X