Mycosis Fungoides: A Rare Entity: A Case Report.

BACKGROUND: Mycosis fungoides (MF) is classically evolved through cutaneous manifestations including patches/plaques, tumors, and generalized erythroderma. Staging classification system for MF and SS is TNMB system, based upon an evaluation of the skin, lymph nodes, visceral involvement, and blood. Treatment modalities includes Topical treatments, Radiotherapy, Phototherapy, chemotherapy, and novel targeted agents CASE REPORT: 36 years old female presented to us with complain of multiple crusted skin lesions, progressively increasing in size. On examination she had generalized patchy erytheroderma, crusted tumor lesion with axillary lymphadenopathy. Biopsy revealed T cell lymphoma. Computed tomography scans revealed multiple enlarged lymph nodes in axilla, and lymph node mass at L1 level. Blood tests showed no atypical cells. Her TNMB stage was T4 Nx M0 B0. Multi-disciplinary tumor board meeting consensus decision comprised of skin-directed therapy and systemic chemotherapy. Due to depth and size of skin tumors, total skin electron therapy (TSET) was recommended for this case with weekly oral methotrexate. Treatment was delivered with extended SSD technique, 350 cm. Prescribed dose was 3600cGy in 24 fractions with 150 cGy dose/fraction. After 1 month follow up visit, patient had no clinical evidence of disease over skin. DISCUSSION: Mycosis fungoides is T cell lymph proliferative disorder that arises primarily in skin. Radiotherapy with electrons of all skin is normally used in patients with history of quick progression of disease with complete response rates after 3 months of treatment vary from 80 to 97%. [ABSTRACT FROM AUTHOR]