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Highly regioselective meta arylation of oxalyl amide-protected β-arylethylamine via the Catellani reaction.
- Source :
- Chemical Communications; 5/25/2016, Vol. 52 Issue 42, p6903-6906, 4p
- Publication Year :
- 2016
-
Abstract
- The first bidentate directing group assisted highly selective meta arylation of β-arylethylamine derivatives via palladium/norbornene catalysis is reported, and the range of aryl iodides for the oxalyl amide assisted meta-selective arylation reactions is broadest yet reported. This meta arylation also proceeds well with thiophene derivatives, giving the corresponding products in satisfactory yields. And three-step functionalization of arylethyloxalamide with three different functional groups is successfully performed. [ABSTRACT FROM AUTHOR]
- Subjects :
- ARYLATION
OXALYL chloride
AMIDES
CHEMICAL reactions
PALLADIUM
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 52
- Issue :
- 42
- Database :
- Complementary Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 115407788
- Full Text :
- https://doi.org/10.1039/c6cc02384c