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MnSOD and CAT polymorphisms modulate the effect of the Mediterranean diet on breast cancer risk among Greek-Cypriot women.
- Source :
- European Journal of Nutrition; Jun2016, Vol. 55 Issue 4, p1535-1544, 10p, 2 Diagrams, 4 Charts
- Publication Year :
- 2016
-
Abstract
- Purpose: Oxidative stress arises due to a cellular imbalance in oxidants and antioxidants and/or due to an altered activity of antioxidant enzymes, caused by SNPs. Oxidative stress increases susceptibility to breast cancer (BC) risk, and we previously showed that the Mediterranean diet (MD), which is rich in antioxidants, reduces BC risk in Greek-Cypriot women. Here, we investigated the effect of MnSOD (p.Val16Ala, rs4880) and CAT (-262C>T, rs1001179) SNPs on the association between the MD and BC risk in the case-control study of BC MASTOS in Cyprus. Methods: Dietary intake data were obtained using a 32-item food frequency questionnaire, from which a dietary pattern was previously derived, using principal component analysis. This pattern included high loadings of vegetables, fruit, legumes and fish, a combination that closely resembles the MD and was used as our dietary variable. Results: High vegetable intake lowered BC risk in women with at least one MnSOD Val allele (OR for Val/Val = 0.56, 95 % CI 0.35-0.88, for Val/Ala = 0.57, 95 % CI 0.39-0.82), or one CAT -262C allele (OR for -262CC = 0.66, 95 % CI 0.47-0.92, for -262CT = 0.53, 95 % CI 0.35-0.81). High fish intake conferred a decreased BC risk of CAT -262CC women (OR 0.66, 95 % CI 0.47-0.92) compared with the CAT -262TT women and low fish intake (OR 2.79, 95 % CI 1.08-7.17). Additionally, high fish intake reduced BC risk in MnSOD Val/Val women (OR 0.63, 95 % CI 0.40-0.98). p interaction values were, however, not statistically significant. Conclusion: Our results demonstrate that the antioxidative effects of the MD against BC risk may be enhanced by the wild-type alleles of the MnSOD or CAT SNPs among Greek-Cypriot women. [ABSTRACT FROM AUTHOR]
- Subjects :
- BREAST tumor risk factors
MEDITERRANEAN diet
DIET therapy for cancer patients
NUTRITIONAL assessment
VEGETABLES
CONFIDENCE intervals
GENETIC polymorphisms
ANTIOXIDANTS
ALLELES
CASE-control method
INTERVIEWING
GREEK Cypriots
NUTRITIONAL genomics
RESEARCH funding
QUESTIONNAIRES
FACTOR analysis
FISHES
DESCRIPTIVE statistics
CHI-squared test
GENOTYPES
LOGISTIC regression analysis
ODDS ratio
DATA analysis software
WOMEN'S health
EPIDEMIOLOGICAL research
PROBABILITY theory
Subjects
Details
- Language :
- English
- ISSN :
- 14366207
- Volume :
- 55
- Issue :
- 4
- Database :
- Complementary Index
- Journal :
- European Journal of Nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 115529578
- Full Text :
- https://doi.org/10.1007/s00394-015-0971-5