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Epstein-Barr Virus EBNA-2 Polymorphic Patterns in Nasopharyngeal Carcinoma in Southern China.

Authors :
Wu, Guocai
Liu, Xia
Liu, Song
Shu, Jun
Sun, Zhifu
Luo, Bing
Source :
Intervirology; May2016, Vol. 58 Issue 6, p386-392, 7p
Publication Year :
2016

Abstract

Objectives: The aim of this study was to characterize the specific Epstein-Barr virus (EBV) polymorphisms from nasopharyngeal carcinoma (NPC) patients and healthy donors in Southern China, and to explore the relationship between EBV genotypes and NPC. Methods: The EBNA-2 gene of 32 EBV-positive NPCs and 39 EBV-positive throat washing (TW) samples from healthy individuals from Southern China was analyzed using PCR and sequencing. Results: We found E2-A to be the predominant subtype in Southern China. The distribution of EBNA-2 subtypes between NPCs and TWs was significantly different (p < 0.01) and the E2-A subtype was overly represented in NPCs. Conclusions: E2-A is the predominant subtype in Southern China, and the distribution of EBNA-2 subtypes between NPCs and TWs is significantly different. In Southern China, the E2-A subtype is significantly more frequent in NPCs than TWs, and is also more common than in Northern China. This suggests that the E2-A subtype may play an important role in the pathogenesis of NPC and that EBNA-2 gene variations are tumor-specific polymorphisms. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03005526
Volume :
58
Issue :
6
Database :
Complementary Index
Journal :
Intervirology
Publication Type :
Academic Journal
Accession number :
115856272
Full Text :
https://doi.org/10.1159/000444920